Structure of Bruch’s Membrane in the Young Adult Eye
نویسنده
چکیده
Bruch’s membrane is a thin (2–4 μm), acellular, five-layered extracellular matrix located between the retina and choroid. It extends anteriorly to the ora serrata, interrupted only by the optic nerve. Tissue resembling Bruch’s membrane is visible anterior to the ora serrata extending forward to the pigmented epithelium of the ciliary body. Bruch’s membrane lies between the metabolically active retinal pigment epithelium (RPE) and a capillary bed (choriocapillaris) and thus serves two major functions as the substratum of the RPE and a vessel wall. It has major clinical significance because of its involvement in agerelated macular degeneration (AMD) and other chorioretinal diseases.
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